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CISDOC database

Document ID (ISN)28510
CIS number 78-134
ISSN - Serial title Tijdschrift voor sociale geneeskunde
Year 1977
Convention or series no.
Author(s) Mattern I.E.
Title The Ames test, a rapid early screening method for mutagenic and carcinogenic substances
Original title De Ames-test, een snelle pre-screeningsmethode voor mutagene en carcinogene stoffen [in Dutch]
Bibliographic information 23 Feb. 1977, Vol.55, No.4, p.136-139. Illus. 8 ref.
Abstract Description of a test for the early detection of the triggering of mutation processes in bacteria due to chemical compounds. Before being tested the substances undergo metabolic activation of mammalian microsomal enzymes (liver homogenate). The results obtained in using this simple and rapid test on the effects of some 300 substances showed a correlation between mutagenicity and mammalian carcinogenicity.
Descriptors (primary) mutagens; biochemical tests; hazard evaluation; carcinogens
Descriptors (secondary) metabolic process; description of technique; in vitro experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Risk evaluation