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Document ID (ISN)28499
CIS number 78-132
ISSN - Serial title 0049-8610 - Zeitschrift fŘr die gesamte Hygiene und ihre Grenzgebiete
Year 1977
Convention or series no.
Author(s) Baer H.P., Bech R., Franke J., Grunewald A., Kochmann W., Melson F., Runge H., Wiedner W.
Title Results of experiments in rabbits with sodium fluoride and antidotes
Original title Ergebnisse tierexperimenteller Untersuchungen an Kaninchen mit Natriumfluorid unter Einwirkung von Gegenmitteln [in German]
Bibliographic information Jan. 1977, Vol.23, No.1, p.14-20. Illus. 49 ref.
Abstract 7mg/kg fluoride was administered daily for a year. Fluorosis varied individually, but was of only minor degree. Equivalent quantities of boron and iron given daily as antidotes increased urinary fluoride excretion, normalised the enzyme system in the blood serum, reduced the fluoride content of bone on chemical analysis, and prevented thickening of the cortex of the long bones, as radiological and histological investigations showed. Prolonged administration of iron gave rise to toxic side effects and finally osteoporosis. Boron generally had a better antagonistic effect on fluoride and caused no toxic side effects.
Descriptors (primary) iron; boron; chronic poisoning; antidote treatment; sodium fluoride
Descriptors (secondary) fluorides; animal experiments; skeletal fluorosis; osteoporosis
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Inorganic substances
Halogens and their inorganic compounds
Iron and compounds