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Document ID (ISN)27896
CIS number 77-1632
ISSN - Serial title 0091-6749 - Journal of Allergy and Clinical Immunology
Year 1977
Convention or series no.
Author(s) Butcher B.T., Salvaggio J.E., O'Neil C.E., Weill H., Garg O.
Title Toluene diisocyanate pulmonary disease: immunopharmacologic and mecholyl challenge studies.
Bibliographic information Mar. 1977, Vol.59, No.3, p.223-227. Illus. 30 ref.
Abstract Workers showing clinical sensitivity to tolylene diisocyanate (TDI) were studied for (1) in vitro TDI-induced leukocyte histamine release; (2) determination of cyclic 3',5'-adenosine monophosphate (cAMP) levels in lymphocytes exposed to TDI; (3) effect of TDI on the isoproterenol-induced increase in lymphocyte cAMP levels; and (4) acetyl-β-methylcholine (mecholyl) inhalation challenge. TDI did not induce histamine release; lymphocyte cAMP levels were not affected by TDI exposure; stimulation of lymphocyte cAMP by isoproterenol was reduced; when challenged with mecholyl, 7 of 10 sensitive individuals had a greater than 20% decrease in FEV1 (1 of 10 controls). TDI-induced obstructive airways disorders may be associated with altered β-adrenergic function.
Descriptors (primary) allergens; hypersensitivity; immunology; tolylene diisocyanate
Descriptors (secondary) obstructive ventilatory impairment; 2,4-tolylene diisocyanate; histamine release; comparative study; respiratory function tests; serological reactions; inhalation tests
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Isocyanates
Cyano compounds