Document ID (ISN) | 27896 |
CIS number |
77-1632 |
ISSN - Serial title |
0091-6749 - Journal of Allergy and Clinical Immunology |
Year |
1977 |
Convention or series no. |
|
Author(s) |
Butcher B.T., Salvaggio J.E., O'Neil C.E., Weill H., Garg O. |
Title |
Toluene diisocyanate pulmonary disease: immunopharmacologic and mecholyl challenge studies. |
Bibliographic information |
Mar. 1977, Vol.59, No.3, p.223-227. Illus. 30 ref. |
Abstract |
Workers showing clinical sensitivity to tolylene diisocyanate (TDI) were studied for (1) in vitro TDI-induced leukocyte histamine release; (2) determination of cyclic 3',5'-adenosine monophosphate (cAMP) levels in lymphocytes exposed to TDI; (3) effect of TDI on the isoproterenol-induced increase in lymphocyte cAMP levels; and (4) acetyl-β-methylcholine (mecholyl) inhalation challenge. TDI did not induce histamine release; lymphocyte cAMP levels were not affected by TDI exposure; stimulation of lymphocyte cAMP by isoproterenol was reduced; when challenged with mecholyl, 7 of 10 sensitive individuals had a greater than 20% decrease in FEV1 (1 of 10 controls). TDI-induced obstructive airways disorders may be associated with altered β-adrenergic function. |
Descriptors (primary) |
allergens; hypersensitivity; immunology; tolylene diisocyanate |
Descriptors (secondary) |
obstructive ventilatory impairment; 2,4-tolylene diisocyanate; histamine release; comparative study; respiratory function tests; serological reactions; inhalation tests |
Document type |
- |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
|
Browse category(ies) |
Isocyanates Cyano compounds
|