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Document ID (ISN)27658
CIS number 77-1415
ISSN - Serial title 0004-1254 - Arhiv za higijenu rada i toksikologiju
Year 1976
Convention or series no.
Author(s) Muačević G.
Title Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos.
Bibliographic information 1976, Vol.27, No.1, p.3-14. Illus. 11 ref.
Abstract The acute dermal toxicity, neurotoxicity, eye mucosa compatibility and cholinesterase inhibition of the insecticide was tested in animals. The oral, LD50 values obtained are: rat, 13mg/kg; mouse, 141mg/kg; guinea-pig, 58mg/kg; rabbit, 20mg/kg; quail, 45mg/kg; hen, 45mg/kg; and dermal LD50 for: rat, 58mg/kg and for rabbit, 48mg/kg. No signs of neurotoxicity in hens were observed. In rats, a maximal inhibition of erythrocyte cholinesterase was found after 2h, of plasma cholinesterase after 4 and of brain cholinesterase after 6h, with a reversal to normal in the blood observed after 4 days and in brain after 8 days. Lindane and phenobarbital pretreatment reduced the acute toxicity of chlorthiophos. Atropine, obidoxime chloride and trimedoxime bromide antagonised the toxic effects of chlorthiophos.
Descriptors (primary) chlorthiophos; cholinesterase; toxicology; insecticides; enzyme disturbances
Descriptors (secondary) neurotoxic effects; antagonistic effects; lindane; obidoxime; 2-pam(cl); dermal toxicity; phenobarbital; antidote treatment; animal experiments; lethal dose 50; trimedoxime
Document type -
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s)
Browse category(ies) Blood diseases
Esters and salts
Agricultural chemicals