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CISDOC database

Document ID (ISN)27071
CIS number 77-750
ISSN - Serial title 0300-483X - Toxicology
Year 1976
Convention or series no.
Author(s) Lake B.G., Brantom P.G., Gangolli S.D., Butterworth R., Grasso P.
Title Studies on the effects of orally administered di(2-ethylhexyl) phthalate in the ferret.
Bibliographic information Nov.-Dec. 1976, Vol.6, No.3, p.341-355. Illus. 14 ref.
Abstract A target-organ study of the effects of this ester (DEHP, also known as DOP) was conducted in mature male albino ferrets. DEHP treatment caused a loss of body weight when administered as a 1% (w/w) diet for 14 months. Additionally, liver enlargement with associated morphological and biochemical changes were observed. These changes consisted of liver cell enlargement, lysosomal changes, dilatation of the endoplasmic reticulum and the depression of a number of marker enzyme activities. The only other tissue observed to be affected by DEHP treatment was the testes where histological evidence of tissue damage was observed in some animals. DEHP was metabolised in the ferret to derivatives of mono(2-ethylhexyl) phthalate which were excreted in the urine both unconjugated and as glucoronides. The results were compared with previous studies in the rat; DEHP is hepatotoxic in both species.
Descriptors (primary) hepatotoxic effects; toxicology; enzyme disturbances; bis(ethylhexyl) phthalate
Descriptors (secondary) animal experiments; biological effects; histopathology; gonadotropic effects
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Blood diseases
Phthalates
Esters and salts
Genetic factors in reaction to exposures