|Document ID (ISN)||27035|
|ISSN - Serial title
||0013-9351 - Environmental Research
|Convention or series no.
||Seth P.K., Srivastava S.P., Agarwal D.K., Chandra S.V.
||Effect of di-2-ethylhexyl phthalate (DEHP) on rat gonads.
||Oct. 1976, Vol.12, No.2, p.131-138. Illus. 20 ref.
||Enzymic and pathological changes in rat gonads were studied after injection of bis(2-ethylhexyl) phthalate. Succinic dehydrogenase and adenosine triphosphatase activities decreased suggesting energy metabolism impairment. β-Glucuronidase activity increased suggesting alterations involving lysosomes and the endoplasmic reticulum. The testis of the treated animals showed thickened tunica albuginea and degeneration of epithelium. There were no detectable differences between the ovaries of normal and treated rats.
||bis(ethylhexyl) phthalate; enzyme disturbances; plasticizers; gonadotropic effects; toxicology
||phthalates; histopathology; animal experiments
||Toxic and dangerous substances
|Broad subject area(s)
Antifertility and prenatal effects
Esters and salts
Genetic factors in reaction to exposures