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CISDOC database

Document ID (ISN)27035
CIS number 77-744
ISSN - Serial title 0013-9351 - Environmental Research
Year 1976
Convention or series no.
Author(s) Seth P.K., Srivastava S.P., Agarwal D.K., Chandra S.V.
Title Effect of di-2-ethylhexyl phthalate (DEHP) on rat gonads.
Bibliographic information Oct. 1976, Vol.12, No.2, p.131-138. Illus. 20 ref.
Abstract Enzymic and pathological changes in rat gonads were studied after injection of bis(2-ethylhexyl) phthalate. Succinic dehydrogenase and adenosine triphosphatase activities decreased suggesting energy metabolism impairment. β-Glucuronidase activity increased suggesting alterations involving lysosomes and the endoplasmic reticulum. The testis of the treated animals showed thickened tunica albuginea and degeneration of epithelium. There were no detectable differences between the ovaries of normal and treated rats.
Descriptors (primary) bis(ethylhexyl) phthalate; enzyme disturbances; plasticizers; gonadotropic effects; toxicology
Descriptors (secondary) phthalates; histopathology; animal experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Blood diseases
Antifertility and prenatal effects
Esters and salts
Genetic factors in reaction to exposures