| Document ID (ISN) | 27035 |
| CIS number |
77-744 |
| ISSN - Serial title |
0013-9351 - Environmental Research |
| Year |
1976 |
| Convention or series no. |
|
| Author(s) |
Seth P.K., Srivastava S.P., Agarwal D.K., Chandra S.V. |
| Title |
Effect of di-2-ethylhexyl phthalate (DEHP) on rat gonads. |
| Bibliographic information |
Oct. 1976, Vol.12, No.2, p.131-138. Illus. 20 ref. |
| Abstract |
Enzymic and pathological changes in rat gonads were studied after injection of bis(2-ethylhexyl) phthalate. Succinic dehydrogenase and adenosine triphosphatase activities decreased suggesting energy metabolism impairment. β-Glucuronidase activity increased suggesting alterations involving lysosomes and the endoplasmic reticulum. The testis of the treated animals showed thickened tunica albuginea and degeneration of epithelium. There were no detectable differences between the ovaries of normal and treated rats. |
| Descriptors (primary) |
bis(ethylhexyl) phthalate; enzyme disturbances; plasticizers; gonadotropic effects; toxicology |
| Descriptors (secondary) |
phthalates; histopathology; animal experiments |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Esters and salts
Phthalates
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Blood diseases
|
