ILO Home
Go to the home page
Site map | Contact us Français | Español

CISDOC database

Document ID (ISN)27026
CIS number 77-739
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1976
Convention or series no.
Author(s) Young J.D., Braun W.H., Gehring P.J., Horvath B.S., Daniel R.L.
Title 1,4-dioxane and β-hydroxyethoxyacetic acid excretion in urine of humans exposed to dioxane vapors.
Bibliographic information Dec. 1976, Vol.38, No.3, p.643-646. 8 ref.
Abstract An average of 3.5µM/l 1,4-dioxane and 414µM/l β-hydroxyethoxyacetic acid (HEAA) daily were found in the urine of dioxane plant personnel exposed to 1.6ppm dioxane. The biotransformation of dioxane is thus similar to that found in rats. The high ratio of HEAA to dioxane suggests that dioxane is rapidly metabolised, and that exposure to low concentrations of dioxane vapour presents a neglible hazard.
Descriptors (primary) chemical industry; metabolic process; urinary metabolites; toxicology; dioxane
Descriptors (secondary) human experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Ethers
Chemical industry