| Document ID (ISN) | 26979 |
| CIS number |
77-728 |
| ISSN - Serial title |
0041-008X - Toxicology and Applied Pharmacology |
| Year |
1976 |
| Convention or series no. |
|
| Author(s) |
Kopp S.J., Hawley P.L. |
| Title |
Factors influencing cadmium toxicity in A-V conduction system of isolated perfused rat heart. |
| Bibliographic information |
Sep. 1976, Vol.37, No.3, p.531-544. 51 ref. |
| Abstract |
At pH 7.2, progressive P-R interval increase with partial Type I A-V block occurred in 6 of 8 hearts exposed to 3 x 10-2mM Cd2+, and in 1 of 5 exposed to 1/10 of this concentration; at pH 6.8 and 7.0, complete A-V block occurred in all hearts perfused with the former dose, and in 5 of 8 hearts at pH 7.4 and 7.6. Atrial activity persisted in all cases of A-V block. Concentrations of >3 x 10-4mM cadmium significantly reduced heart rate. Cadmium appears to be a specific depressant of A-V conduction and its effects are more rapid and less reversible as the pH decreases. Metal mercaptide formation via sulfhydryl binding at the membrane surface may be involved in the effect. |
| Descriptors (primary) |
electrocardiographic changes; cadmium; cardiotoxic effects; toxicology |
| Descriptors (secondary) |
nervous conduction disorders; animal experiments; heart block; bradycardia |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Inorganic substances
Cardiovascular diseases
Cadmium and compounds
|
