| Document ID (ISN) | 26869 |
| CIS number |
77-475 |
| ISSN - Serial title |
0041-008X - Toxicology and Applied Pharmacology |
| Year |
1976 |
| Convention or series no. |
|
| Author(s) |
Moroi K., Ushiyama S., Satoh T., Kuga T. |
| Title |
Enzyme induction by repeated administration of tetrachlorvinphos in rats. |
| Bibliographic information |
Aug. 1976, Vol.37, No.2, p.377-386. 22 ref. |
| Abstract |
A single dose of 250 or 1,000mg/kg tetrachlorvinphos (TCVP - 2-chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate) inhibited erythrocyte cholinesterase (ChE) more than serum or brain ChE. Oral doses of 60 and 250mg/kg for 10 days produced dose-related increases in the activity of aminopyrine demethylase and EPN (O-ethyl O-(p-nitrophenyl) phenylphosphonothioate) detoxifiction enzyme. Relative liver weight first increased and then decreased. Repeated administration of TCVP induced the enzymes responsible for its metabolism up to 7-fold in microsomes and 1.2-fold in the supernatant. |
| Descriptors (primary) |
phosphoric acid esters; insecticides; enzyme disturbances; tetrachlorvinphos |
| Descriptors (secondary) |
metabolic detoxication; liver; in vitro experiments; animal experiments; cholinesterase |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Agricultural chemicals
Blood diseases
Esters and salts
|
