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Document ID (ISN)26213
CIS number 76-1947
ISSN - Serial title 0097-6326 - Federal Register
Year 1976
Convention or series no.
National Institutes of Health, Department of Health, Education and Welfare, Washington, D.C.
Title Carcinogenesis bioassay of technical grade chlordecone (Kepone).
Bibliographic information 8 Apr. 1976, Vol.41, No.69, p.14914-14915.
Abstract Chlordecone (Kepone) was administered to rats and mice for 80 weeks beginning with doses that were not well tolerated and decreasing to doses that averaged 8 and 24ppm for male rats, 18 and 26ppm for female rats, 20 and 23ppm for male mice and 20 and 40ppm for female mice. Generalised tremors and dermatologic changes were noted and there was a significant increase in hepatocellular carcinomas of high dose level rats and of mice at both levels. Extensive hyperplasia of the liver was also found. (Single copies of the report are available from the Office of Cancer Communications, National Cancer Institute, Building 31, Room 10A21, National Institutes of Health, Bethesda, Maryland 20014).
Descriptors (primary) carcinogens; toxicology; insecticides; kepone
Descriptors (secondary) USA; hepatotoxic effects; report; neoplasms; animal experiments; dose-response relationship; liver cancer
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Halogenated hydrocarbons
Agricultural chemicals