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Document ID (ISN)26176
CIS number 76-1933
ISSN - Serial title Munkavédelem
Year 1976
Convention or series no.
Author(s) Király J., Szentesi I., Ruzicska P., Czeizel E.
Title Investigations of chromosomes in workers producing organophosphate insecticides
Original title Kromoszóma-vizsgálatok szerves foszforsav-inszekticideket gyártó munkásokban [in Hungarian]
Bibliographic information 1976, Vol.22, No.7-9, p.27-33. 19 ref.
Abstract Data was compared of workers producing or formulating trichlorphon (Ditrifon 50, chlorophos), diazinon (Basudin E), and Prolate (Safidone 40 WP, phosmet) with those of an unexposed control group, a prolonged indirect-exposure group ("factory control") and a "positive control" group producing tetrachlorobenzene. The frequency of chromatide-type aberrations and acentric fragments increased considerably in the factory control group in relation to the normal controls. Diazinon and Prolate caused an increase in the 3 types of structure deformations, while trichlorophon provoked a slight increase in chromosome-type deformities compared to the factory control group. The mutagenicity of tetrachlorobenzene was confirmed.
Descriptors (primary) organophosphorus compounds; pesticide production; chromosome changes; insecticides
Descriptors (secondary) phosmet; mutagenic effects; 1,2,4,5-tetrachlorobenzene; chlorophos; diazinon; analysis of chromosome aberrations; organic thiophosphates
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Chemical industry