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CISDOC database

Document ID (ISN)25915
CIS number 76-1665
ISSN - Serial title 0323-9179 - Problemi na higienata
Year 1975
Convention or series no.
Author(s) Hinkova L., Kalojanova F., Dimov S., Acev E.
Title Comparative study of EEG and cholinesterase activity changes in experimental intoxication with dipterex
Original title Sravnitelno izsledvane na promenite v EEG i holinesteraznata aktivnost pri eksperimentalna intoksikacija s diptereks [in Bulgarian]
Bibliographic information 1975, Vol.1, No.1, p.39-44. Illus. 2 ref.
Abstract Dipterex (chlorophos) administered intraperitoneally (3 and 6mg/kg) and intramuscularly (10 and 20mg/kg) in cats inhibited cholinesterase activity in all the experiments, while EEG changes were mild and irregular. Desynchronisation of the spontaneous EEG prevailed after a single dose of dipterex; on activation by photic stimulation, on the other hand, an increase in late negative potentials was predominant. Repeated administration of dipterex gave rise to theta rhythms and activation of pre-existing seizure patterns. Discussion of the correlation between EEG changes and cholinesterase activity.
Descriptors (primary) cholinesterase; enzyme disturbances; chlorophos; electroencephalographic changes; insecticides
Descriptors (secondary) neurotoxic effects; comparative study; animal experiments; organophosphorus compounds
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Mental health
Blood diseases
Esters and salts