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CISDOC database

Document ID (ISN)25768
CIS number 76-1624
ISSN - Serial title 0091-6765 - Environmental Health Perspectives
Year 1976
Convention or series no.
Author(s) Kuz'minskaya U.A., Alekhina S.M.
Title Effect of chlorocamphene on the isoenzyme spectrum of lactate dehydrogenase in rat serum and liver.
Bibliographic information Research Triangle Park, USA, Feb. 1976, Vol.13, p.127-132. Illus. 21 ref.
Abstract Total lactate dehydrogenase (LDH) decreases in the liver of rats after ingestion of a single dose of half the LD50 (120mg/kg) of toxaphene (polychlorocamphene, chlorocamphene). The isoenzyme spectrum of LDH is characterised by an increase in LDH1, LDH2, and LDH3, and by a decrease in LDH4. The overall LDH activity does not change in blood serum. The isoform ratio changes insignificantly and LDH1 falls, but normalises 15 days after the administration of the compound. Ingestion of toxaphene at levels 1/100 the LD50 daily over 1, 3 and 6 months causes a reduction in the overall LDH activity in the liver and serum. LDH1 and LDH4 decrease and LDH2 and LDH3 increase in blood serum. Beginning with the 3rd month of administration, LDH1 tends to return to normal levels. LDH2, LDH3 and LDH4 do return to normal levels, while LDH5 increases regularly. It can be considered that the ingestion of toxaphene does not result in an increase in the permeability of the cell membranes of the liver for LDH isoenzymes, while the isoenzyme spectrum shifts in serum are either the result of the biosynthesis of the isoforms of this enzyme changed by the compound or the result of the permeability for them of the cells of other tissues.
Descriptors (primary) liver; toxaphene; toxicology; pesticides; enzyme disturbances
Descriptors (secondary) lactate dehydrogenase; polychlorinated terpenes; animal experiments; chlorinated hydrocarbons; serum changes
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Blood diseases
Halogenated hydrocarbons