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CISDOC database

Document ID (ISN)25723
CIS number 76-1616
ISSN - Serial title 0095-6562 - Aviation, Space, and Environmental Medicine
Year 1976
Convention or series no.
Author(s) Revzin A.M.
Title Effects of organophosphate pesticides and other drugs on subcortical mechanisms of visual integration.
Bibliographic information June 1976, Vol.47, No.6, p.627-629. Illus. 10 ref.
Abstract Atropine, scopolamine, mevinphos, and eserine selectively block directional sensitivity of visual integrative neurones in the thalamus. Cholinergic drugs that do not penetrate the blood-brain barrier are without effect. The neurones studied are important links in reflex brain systems controlling visual attention and eye movements. The results suggest that any cholinergic drug that can reach the brain will disturb visual functions. Since the changes are qualitative and the system is reflex, the affected individual may be unaware of dysfunction. The resultant dangers to aerial applicators are discussed, particularly with respect to atropine, which is necessary in the therapy of organophosphate and carbamate poisoning but is potentially harmful if self-administered for either prophylaxis or treatment.
Descriptors (primary) neurotoxic effects; visual function disorders; pesticides; drugs; organophosphorus compounds
Descriptors (secondary) scopolamine; mevinphos; physostigmine; contraindication; aircraft; crop protection; animal experiments; atropine
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Diseases of the eye and vision damage
Diseases of the nervous system