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CISDOC database

Document ID (ISN)25722
CIS number 76-1615
ISSN - Serial title 0095-6562 - Aviation, Space, and Environmental Medicine
Year 1976
Convention or series no.
Author(s) Revzin A.M.
Title Effects of mevinphos (Phosdrin) on unit discharge patterns in avian hippocampus.
Bibliographic information June 1976, Vol.47, No.6, p.608-611. Illus. 14 ref.
Abstract Recent experiments have shown that low doses of the acetylcholinesterase inhibitors, mevinphos and physostigmine, reduce hippocampal inhibitory phenomena, measured in terms of the duration of the poststimulus inhibitory pause seen in individual hippocampal neurones in the pigeon. The cholinergic antagonist, atropine, increased hippocampal inhibition. At near threshold dose mevinphos could, in part, reverse atropine effects. At higher doses, mevinphos synergized with atropine. Any organophosphate or carbamate pesticide and its antidote, atropine, may alter "attention" or "short-term memory" through effects on hippocampus at doses too low to induce grossly detectable peripheral symptomatology. Extreme caution is urged in the use or handling of these compounds by aerial applicators crop dusting with pesticides of this kind. Since the effects of atropine and mevinphos can synergize, the use of atropine to permit poisoned applicators to resume activity is questioned.
Descriptors (primary) neurotoxic effects; crop protection; pesticides; mevinphos
Descriptors (secondary) enzyme inhibition; atropine; cholinesterase; contraindication; animal experiments; synergism; aircraft
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Diseases of the nervous system
Esters and salts