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CISDOC database

Document ID (ISN)25695
CIS number 76-1395
ISSN - Serial title 0036-8075 - Science
Year 1976
Convention or series no.
Author(s) DeBaun J.R., Menn J.J.
Title Sulfoxide reduction in relation to organophosphorus insecticide detoxification.
Bibliographic information 16 Jan. 1976, Vol.191, No.4223, p.187-188. 7 ref.
Abstract Carbophenothion sulfoxide, an oxidative metabolite of carbophenothion (Trithion), is reduced in the living rat by an in vitro system containing rat liver enzyme, reduced nicotinamide adenine dinucleotide phosphate, and flavine adenine dinucleotide phosphate. This reduction of the sulfoxide, which is a more potent cholinesterase inhibitor than the parent sulfide, may represent a general detoxification pathway in animals, plants and other environmental systems.
Descriptors (primary) metabolic detoxication; insecticides; organophosphorus compounds; metabolic process
Descriptors (secondary) carbophenothion; radioactive tracers; animal experiments; enzyme inhibition
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals