| Document ID (ISN) | 25694 |
| CIS number |
76-1394 |
| ISSN - Serial title |
0036-8075 - Science |
| Year |
1976 |
| Convention or series no. |
|
| Author(s) |
Chowdhury P., Louria D.B. |
| Title |
Influence of cadmium and other trace metals on human α1-antitrypsin: an in vitro study. |
| Bibliographic information |
6 Feb. 1976, Vol.191, No.4226, p.480-481. 18 ref. |
| Abstract |
The effect of trace metals on plasma α1-antitrypsin was studied in vitro by adding known concentrations of trace metals, either alone or in combination, to plasma. Cadmium was the only one that reduced the concentration of α1-antitrypsin and depressed the trypsin inhibitory capacity. No effects were found with divalent lead, mercury, nickel, iron and zinc ions. These effects offer a plausible explanation for the emphysema that occurs in industrial workers exposed to cadmium. |
| Descriptors (primary) |
trace metals; cadmium; immunology; emphysema |
| Descriptors (secondary) |
trypsin; iron; nickel; in vitro experiments; zinc; lead; mercury |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Inorganic substances
Diseases of the respiratory system (except for pneumoconiosis & similar)
Cadmium and compounds
|
