|Document ID (ISN)||25617|
|ISSN - Serial title
||Gigiena truda i professional'nye zabolevanija
|Convention or series no.
||Aldyreva M.V., Klimova T.S., Izjumova A.S., Timofeevskaja L.A.
||Effects of phthalate plasticisers on genetic function
||Vlijanie ftalatnyh plastifikatorov na generativnuju funkciju [in Russian]|
||Dec. 1975, p.25-29. Illus. 15 ref.
||A brief literature survey of the effects of phthalates on women (tendency to difficult pregnancy, miscarriage and anovulation) is followed by the results of research on pregnant female rats to which dibutyl (DBP), dioctyl and other phthalates were administered intragastrically. Administration of DBP during the development of the placenta resulted in a considerable reduction in placenta weight as compared with the controls. On the contrary, the weight of the embryo was above normal, except in cases where DBP was administered on the 11th day of pregnancy. The authors observed a direct dose-response relationship between dose and embryotropic effects.
||embryotoxic effects; phthalates; plasticizers; women; genetic effects
||literature survey; dioctyl phthalate; dinonyl phthalate; didodecyl phthalate; benzyl butyl phthalate; diethyl phthalate; dibutyl phthalate; animal experiments; dose-response relationship; dimethyl phthalate
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Esters and salts
Genetic factors in reaction to exposures