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Document ID (ISN)25617
CIS number 76-1366
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1975
Convention or series no.
Author(s) Aldyreva M.V., Klimova T.S., Izjumova A.S., Timofeevskaja L.A.
Title Effects of phthalate plasticisers on genetic function
Original title Vlijanie ftalatnyh plastifikatorov na generativnuju funkciju [in Russian]
Bibliographic information Dec. 1975, p.25-29. Illus. 15 ref.
Abstract A brief literature survey of the effects of phthalates on women (tendency to difficult pregnancy, miscarriage and anovulation) is followed by the results of research on pregnant female rats to which dibutyl (DBP), dioctyl and other phthalates were administered intragastrically. Administration of DBP during the development of the placenta resulted in a considerable reduction in placenta weight as compared with the controls. On the contrary, the weight of the embryo was above normal, except in cases where DBP was administered on the 11th day of pregnancy. The authors observed a direct dose-response relationship between dose and embryotropic effects.
Descriptors (primary) embryotoxic effects; phthalates; plasticizers; women; genetic effects
Descriptors (secondary) literature survey; dioctyl phthalate; dinonyl phthalate; didodecyl phthalate; benzyl butyl phthalate; diethyl phthalate; dibutyl phthalate; animal experiments; dose-response relationship; dimethyl phthalate
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Antifertility and prenatal effects
Phthalates
Esters and salts
Genetic factors in reaction to exposures