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Document ID (ISN)25372
CIS number 76-1073
Year 1975
Convention or series no.
Author(s) Petersen R.V., Lyman D.J., Roll D.B., Swinyard E.A.
Title Toxicology of plastic devices having contact with blood.
Bibliographic information PB-244 753/OWV, National Technical Information Service, Springfield, Virginia 22151, USA, 1 May 1975. 122p. 67 ref. Price: Photocopy US-$5.25/Microfiche US-$2.25.
Abstract A collection of papers on the following subjects: acute LD50 of mono-2-ethylhexyl phthalate (MEHP) in mice and rats; sub-acute and local toxicity of MEHP in mice; in vitro uptake of bis(2-ethylhexyl)phthalate (DEHP) by rat heart tissues; DEHP effect on rat heart Na+, K+-ATPase; in vitro metabolism of DEHP by enzyme systems and analyses of organs of calves and humans exposed to cardiac by-pass and renal dialysis procedures; analyses of blood and organs of calves maintained on cardiac by-pass for extended periods of time; localisation of tritiated DEHP in the mouse; fate and metabolism of DEHP in Peromyscus Maniculatus; ultrastructural observations on lung tissue following DEHP administration; effects of DEHP on: hexobarbital sleep time, coagulation time in mice after administration of dicumarol, and reproduction in mice at low dosage; effect of a phthalate plasticiser on blood compatability of polyvinyl chloride; tissue culture studies on MEHP; etc.
Descriptors (primary) blood; metabolic process; plasticizers; phthalates; toxicology; polyvinyl chloride
Descriptors (secondary) particle size distribution; leukocytes; bis(ethylhexyl) phthalate; enzyme disturbances; mono(2-ethylhexyl) phthalate; in vitro experiments; chromosome changes; histopathology; metabolic studies; animal experiments
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Toxicology
Esters and salts
Genetic factors in reaction to exposures