| Document ID (ISN) | 25346 |
| CIS number |
76-1065 |
| ISSN - Serial title |
0025-7818 - Medicina del lavoro |
| Year |
1976 |
| Convention or series no. |
|
| Author(s) |
Gambini G., Farina G., Arbosti G. |
| Title |
Oestroprogestogenic syndrome in a worker involved in production of a contraceptive pharmaceutical |
| Original title |
Sindrome da estroprogestinici in operaio addetto alla produzione di un farmaco anticoncezionale [in Italian] |
| Bibliographic information |
Mar.-Apr. 1976, Vol.67, No.2, p.152-157. Illus. 12 ref. |
| Abstract |
Clinical, laboratory and histological studies in a male worker who had been occupied in weighing out ethynyloestradiol and vinyloestrenolone and mixing them with fillers, over a period of 3-6 days 4 times per year. He presented swelling of the breasts, altered spermatogenesis and psychosexual changes. The causative role of exposure to the hormones is discussed. The exhaust hood employed, and the mask and gloves worn by the worker were not sufficient to limit exposure, and stricter hygiene measures, as well as preventive medical examinations, are recommended. Forensic aspects are briefly referred to. |
| Descriptors (primary) |
hormones; pharmaceutical industry; genetic effects; oestrogens |
| Descriptors (secondary) |
case study; histopathology; vinyloestrenolone; ethynyloestradiol |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Pharmaceutical industry
Genetic factors in reaction to exposures
Antifertility and prenatal effects
|
