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CISDOC database

Document ID (ISN)25154
CIS number 76-1018
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1975
Convention or series no.
Author(s) Paulet G., Roncin G., Vidal E., Toulouse P., Dassonville J.
Title Fluorocarbons and general metabolism in the rat, rabbit and dog.
Bibliographic information Nov. 1975, Vol.34, No.2, p.197-203. 11 ref.
Abstract The metabolic effects of the inhalation of monofluorotrichloromethane (FC11) and difluorodichloromethane (FC12) were studied in various animal species, both in single exposure and repeated exposure experiments. The results are presented in tabular form and discussed. FC12 at 20% in a single exposure or at 5% in prolonged exposure (15 days) does not induce metabolic reactions. The same is true for FC11 at 2.5%; however, FC11 at 5% does produce significant effects which can be explained by a slowing down of cellular oxidation. With FC11/FC12 mixtures, the effects are clearly due to the presence of FC11.
Descriptors (primary) fluorinated hydrocarbons; metabolic disturbances; toxicology
Descriptors (secondary) dichlorodifluoromethane; animal experiments; inhalation; trichlorofluoromethane
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Fluorocarbons
Endocrine diseases
Halogenated hydrocarbons