ILO Home
Go to the home page
Site map | Contact us Français | Espańol

CISDOC database

Document ID (ISN)25115
CIS number 76-1009
ISSN - Serial title 0009-0573 - Československá hygiena
Year 1975
Convention or series no.
Author(s) Barlogová S., Grunt J.
Title Sensitising properties of some pyridazine compounds
Original title Sensibilizačné vlastnosti niektorých pyridazinónových zlúčenin [in Slovak]
Bibliographic information Jan. 1975, Vol.20, No.1, p.5-9. 11 ref.
Abstract The sensitising effects of 2-phenyl-4,5-dichloro-3-pyridazinone (PCC) and its analogues 2-methyl-4,5-dichloro-3-pyridazinone (MCP) and 2-methyl-4,5-dimethoxy-3-pyridazinone (MMP) were tested experimentally on guinea pigs. These substances were administered in 3 different ways: repeated applications to the surface of the skin, a single intradermal injection with Freund's adjuvant (complete) in the digital pads. Administration of MMP produced no hypersensitisation, whereas administration of PCC and MCP in primarily non-toxic doses resulted in a delayed-type hypersensitivity, the intensity of which was dose-dependent. The antigenic determinant in PCC seems to be the phenyl radical, and in MCP it would appear to be chlorine.
Descriptors (primary) pyridazine derivatives; sensitization; pesticides
Descriptors (secondary) 4,5-dimethoxy-2-methyl-3-pyridazinone; 4,5-dichloro-2-methyl-3-pyridazinone; dose-response relationship; animal experiments; hypersensitivity; 4,5-dichloro-2-phenyl-3-pyridazinone
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Heterocyclic compounds
Agricultural chemicals