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Document ID (ISN)24987
CIS number 76-762
ISSN - Serial title 0300-483X - Toxicology
Year 1975
Convention or series no.
Author(s) Davidson P.P.
Title Dietary fat alteration of plasma cholinesterase response to malathion.
Bibliographic information Sep. 1975, Vol.5, No.1, p.113-115. 4 ref.
Abstract Male rats were fed fat-free, normal-fat, and high-fat test diets. Sub-acute doses of malathion were given subcutaneously and cholinesterase levels were determined. Malathion was chosen because it is the least toxic of the organophosphate cholinesterase-inhibiting pesticides. Statistical analysis of the data showed that malathion inhibits blood cholinesterase to the greatest degree in normal-fat diet animals, with the least effect on high-fat groups, and fat-free subjects fall in between the two groups. An impressive increase in plasma cholinesterase activity was induced by the fat-free diet prior to malathion dosing, an unexpected effect.
Descriptors (primary) organophosphorus compounds; cholinesterase; malathion; toxicology; pesticides
Descriptors (secondary) animal experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Esters and salts
Agricultural chemicals