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CISDOC database

Document ID (ISN)24808
CIS number 76-727
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1975
Convention or series no.
Author(s) Reischl P., Van Gelder G.A., Karas G.G.
Title Auditory detection behavior in parathion-treated squirrel monkeys (saimiri sciureus).
Bibliographic information Oct. 1975, Vol.34, No.1, p.88-101. Illus. 35 ref.
Abstract 4 male squirrel monkeys were systematically exposed to daily oral doses (0.1mg/kg) of technical parathion. There were 4 monkeys in the control group. The exposure period was 148 days. The monkeys had been previously adapted to the laboratory and trained to bar-press in response to 0.1-s tone for hearing threshold testing. Daily threshold testing employed the method of constant stimuli. Hearing thresholds were determined at 500, 1,000, 2,000, 4,000, 8,000 and 16,000Hz. An analysis of variance was performed on hearing thresholds and standard deviations of hearing thresholds. The parathion-exposed group showed a significant (p<0.025) increase in the standard deviation of hearing thresholds after 40 days of parathion exposure. The magnitude of the standard deviation continued to grow for 54 additional days and thereafter declined. Mean hearing thresholds between the control and exposed groups did not vary significantly. Daily oral doses of parathion at 0.1mg/kg caused a decrement in the squirrel monkey's tone-reporting behaviour.
Descriptors (primary) parathion; insecticides; ototoxic effects; hearing threshold; toxicology
Descriptors (secondary) animal experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Esters and salts
Agricultural chemicals