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Document ID (ISN)24600
CIS number 76-432
ISSN - Serial title 0003-9896 - Archives of Environmental Health
Year 1975
Convention or series no.
Author(s) Flowers N.C., Hand R.C., Horan L.G.
Title Concentrations of fluoroalkanes associated with cardiac conduction system toxicity.
Bibliographic information July 1975, Vol.30, No.7, p.353-360. Illus. 14 ref.
Abstract Experiments in dogs showed that when respiratory changes associated with inhalation of fluorocarbons was eliminated by continuous control of ventilation and of blood gases during and after exposure, 10-min exposure to trichloromonofluoromethane never caused death at concentrations below 15%. At 15-17%, 9 animals survived and 7 died, and none survived concentrations above 21%. Death was generally due to profound sinus bradycardia and ultimate asystole. 10-min. exposure to dichlorodifluoromethane caused death only at concentrations above 95%.
Descriptors (primary) fluorinated hydrocarbons; cardiotoxic effects; toxicology
Descriptors (secondary) dichlorodifluoromethane; arrhythmia; animal experiments; bradycardia; trichlorofluoromethane
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Halogenated hydrocarbons