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CISDOC database

Document ID (ISN)24548
CIS number 76-422
ISSN - Serial title 0340-0131 - International Archives of Occupational and Environmental Health
Year 1975
Convention or series no.
Author(s) Hladkß A., Krampl V.
Title Effect of S-methylfenitrothion on the activity of cholinesterase and on the excretion of its metabolites in rats.
Bibliographic information 4 Nov. 1975, Vol.36, No.1, p.67-73. 10 ref.
Abstract The effect of S-methylfenitrothion, the active component of a series of insecticides, on erythrocyte and plasma cholinesterase (ChE) activity and ChE reactivation time was studied. Degradation of S-methylfenitrothion in rats was evaluated from urinary excretion of its metabolite p-nitro-m-cresol. The S-methyl isomer was a more potent ChE inhibitor than fenitrothion. Activity was signficantly reduced even by administration of 1/100 of the LD50. Reactivation of ChE after administration of 2/3 of the LD50 took 6 weeks. Excretion of p-nitro-m-cresol was faster and significantly higher than after fenitrothion administration.
Descriptors (primary) enzyme disturbances; metathion; toxicology; insecticides
Descriptors (secondary) metabolic process; animal experiments; cholinesterase
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Blood diseases
Esters and salts