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CISDOC database

Document ID (ISN)24382
CIS number 76-182
Year 1975
Convention or series no.
Author(s) Burchfiel J.L., Duffy F.H., Sim V.M.
Edgewood Arsenal, Aberdeen Proving Ground, Aberdeen, Maryland.
Title Persistent effects of sarin and dieldrin upon the primate electroencephalogram.
Bibliographic information AD-AOO9 494/6WJ, National Technical Information Service, Springfield, Virginia 22161, USA, Apr. 1975. 23p. Illus. 34 ref. Price: Photocopy US-$3.25/Microfiche US-$2.25.
Abstract Rhesus monkeys were administered sarin or dieldrin in either a single large dose (5µg/kg sarin or 4mg/kg dieldrin i.v.) or multiple smaller doses (a series of 10 intramuscular injections of 1µg/kg sarin or 1mg/kg dieldrin at intervals 1 week apart). Animals receiving the single, large doses showed symptoms of acute poisoning including prolonged electrical seizure activity. Animals receiving the multiple doses did not show these signs of acute toxicity. Electroencephalograms were recorded before exposure and at 24 hours and 1 year after exposure. EEG data were computer-processed to yield frequency spectra, and statistical analyses were performed over standard EEG frequency bands. For both drugs and both dose schedules, there was a significant increase in the relative amount of beta energy in the frontal-central and occipital-temporal cortical EEG which persisted for a year.
Descriptors (primary) neurotoxic effects; sarin; electroencephalographic changes; pesticides; dieldrin
Descriptors (secondary) chlorinated organic compounds; animal experiments; organophosphorus compounds
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Esters and salts
Diseases of the nervous system
Mental health
Halogenated hydrocarbons