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Document ID (ISN)24345
CIS number 76-217
ISSN - Serial title 0013-9351 - Environmental Research
Year 1975
Convention or series no.
Author(s) Richardson J.A., Keil J.E., Sandifer S.H.
Title Catecholamine metabolism in humans exposed to pesticides.
Bibliographic information June 1975, Vol.9, No.3, p.290-294. 13 ref.
Abstract Plasma levels of epinephrine (E) and norepinephrine (NE) and 24-h urinary excretion rates of E, NE, total metanephrines (M), and 3-methoxy-4-hydroxymandelic acid (VMA) were compared in 23 pesticide formulators exposed instensively to a mixture of DDT, parathion, and carbaryl and in 20 control subjects. In the exposed group, total plasma DDT was 38,900ppm and red cell cholinesterase was 11.99ÁM/min/ml as compared, respectively with 6,700ppm and 13.65ÁM/min/ml in the controls. Plasma levels and excretion rates of E were significantly lower in exposed than in control subjects. Excretion rates of NE, M, and VMA, as well as plasma levels of NE, were similar in the 2 groups. Systolic blood pressure correlated with total plasma DDT. Systolic and diastolic pressures were negatively correlated with red cell cholinesterase. These results in humans are not consistent with published data in animals, possibly because of species differences, but more likely because of difference in dosage between the animal studies and human exposure and the possibility that a tolerance to insecticides may be developed in man.
Descriptors (primary) metabolic process; catecholamine excretion; toxicology; pesticides
Descriptors (secondary) parathion; DDT; arterial blood pressure; determination in urine; determination in blood; carbaryl; pesticide production
Document type -
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s)
Browse category(ies) Agricultural chemicals