| Document ID (ISN) | 24213 |
| CIS number |
76-133 |
| ISSN - Serial title |
0007-1072 - British Journal of Industrial Medicine |
| Year |
1975 |
| Convention or series no. |
|
| Author(s) |
Roels H.A., Buchet J.P., Lauwerys R.R., Sonnet J. |
| Title |
Comparison of in vivo effect of inorganic lead and cadmium on glutathione reductase system and δ-aminolevulinate dehydratase in human erythrocytes. |
| Bibliographic information |
Aug. 1975, Vol.32, No.3, p.181-192. 75 ref. |
| Abstract |
In these studies, performed with the finanical support of the Commission of the European Communities, erythrocyte δ-aminolaevulinic acid dehydratase (ALAD), blood lead (PbB) and cadmium (CdB), the erythrocyte content of reduced glutathione (GSH), and the regeneration rate of GSH by intact erythrocytes, were measured in 84 men from a cadmium- and lead-producing plant and in 26 controls. The logarithm of PbB showed a strong inverse correlation with the log of ALAD activity and a significant negative correlation with GSH, but neither correlation held good for log CdB. Results showed the overall activity of the glutathione oxidation-reduction pathway not to be impaired in workers with high PbB and CdB levels. It is postulated that the moderate fall in endogenous erythrocyte GSH found in lead-exposed workers might result from lead-induced impairment of the erythrocyte mechanism of glutathione synthesis. |
| Descriptors (primary) |
lead; ALAD; non-ferrous metal industries; cadmium; enzyme disturbances |
| Descriptors (secondary) |
glutathione reductase; comparative study; determination in blood; exposure evaluation |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Inorganic substances
Cadmium and compounds
Blood diseases
Smelting and refining operations
Lead and compounds
|
