| Document ID (ISN) | 24158 |
| CIS number |
75-1966 |
| ISSN - Serial title |
0041-008X - Toxicology and Applied Pharmacology |
| Year |
1975 |
| Convention or series no. |
|
| Author(s) |
Goldstein J.A., Hickman P., Burse V.W., Bergman H. |
| Title |
A comparative study of two polychlorinated biphenyl mixtures (Aroclors 1242 and 1016) containing 42% chlorine on induction of hepatic porphyria and drug metabolizing enzymes. |
| Bibliographic information |
June 1975, Vol.32, No.3, p.461-473. Illus. 32 ref. |
| Abstract |
Aroclor 1242 and Aroclor 1016 were fed to female rats in doses of 100 or 500ppm. At 1 week, Aroclor 1242 markedly increased liver weight and enhanced all drug-metabolising pathways investigated, while Aroclor 1016 had only minimal effects. At 6 months, however, 500ppm of both markedly increased drug metabolism, while Aroclor 1016 was much less effective than Aroclor 1242 at the 100ppm level. Both doses of Aroclor 1242, but only the higher dose of Aroclor 1016, produced porphyria. The marked differences in the biological effects of the two mixtures cannot be explained by differences in absorption, metabolism or excretion. |
| Descriptors (primary) |
liver; polychlorinated biphenyls; porphyria; toxicology; metabolic disturbances; enzyme disturbances |
| Descriptors (secondary) |
hepatotoxic effects; Aroclor 1016; Aroclor 1242; determination in tissues; animal experiments; in vitro experiments; drugs |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Halogenated hydrocarbons
Endocrine diseases
Metabolic diseases
Blood diseases
|
