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CISDOC database

Document ID (ISN)24051
CIS number 75-1942
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1975
Convention or series no.
Author(s) Rider J.A., Puletti E.J., Swader J.I.
Title The minimal oral toxicity level for mevinphos in man.
Bibliographic information Apr. 1975, Vol.32, No.1, p.97-100. Illus. 4 ref.
Abstract To determine the safe exposure level for organophosphate insecticide, mevinphos (2-carbomethoxy-1-methylvinyl dimethyl phosphate) was fed to human volunteers for 30 days. The depression of cholinesterase activity was used as the criterion. None of the 1.0, 1.5, 2.0, or 2.5mg daily doses affected plasma cholinesterase. The 1.0mg had no effect; 1.5 and 2.0mg produced a 20% or greater decrease in erythrocyte cholinesterase on one occasion, whilst 2.5mg produced a steady decrease. It appears that this amount is the level of minimal incipient toxicity.
Descriptors (primary) mevinphos; cholinesterase; toxicology; insecticides; enzyme disturbances
Descriptors (secondary) phosphoric acid esters; human experiments; toxicity evaluation; ingestion
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Blood diseases
Esters and salts