ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)24047
CIS number 75-1939
ISSN - Serial title 0002-8894 - American Industrial Hygiene Association Journal
Year 1975
Convention or series no.
Author(s) Moffitt A.E., Clary J.J., Lewis T.R., Blanck M.D., Perone V.B.
Title Absorption, distribution and excretion of terephthalic acid and dimethyl terephthalate.
Bibliographic information Aug. 1975, Vol.36, No.8, p.633-641. 15 ref.
Abstract Structural formulae and physical and chemical properties of terephthalic acid (TA) and dimethyl terephthalate (DMT). Radiotracer studies in rabbits and rats using C-14-labelled TA and DMT showed: (1) rapid absorption and excretion of DA and DMT without evidence of tissue accumulation on single or repeated oral and intratracheal administration; (2) no skin irritation after single or repeated dermal application, and no significant skin absorption of TA; (3) recovery of 11-13% of the (single or repeated) cutaneous doses from urine and faeces within 10 days; (4) no significant absorption of TA after ocular instillation; (5) 33% excretion of a single ocular dose of DMT, with no evidence of tissue accumulation or eye damage. TA and DMT thus appeared to be rapidly absorbed and excreted without significant accumulation in the tissues.
Descriptors (primary) metabolic process; toxicology; dimethyl terephthalate; terephthalic acid
Descriptors (secondary) detection by radioactivity; routes of entry; body retention; animal experiments; excretion
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Phthalates
Esters and salts