| Document ID (ISN) | 24047 |
| CIS number |
75-1939 |
| ISSN - Serial title |
0002-8894 - American Industrial Hygiene Association Journal |
| Year |
1975 |
| Convention or series no. |
|
| Author(s) |
Moffitt A.E., Clary J.J., Lewis T.R., Blanck M.D., Perone V.B. |
| Title |
Absorption, distribution and excretion of terephthalic acid and dimethyl terephthalate. |
| Bibliographic information |
Aug. 1975, Vol.36, No.8, p.633-641. 15 ref. |
| Abstract |
Structural formulae and physical and chemical properties of terephthalic acid (TA) and dimethyl terephthalate (DMT). Radiotracer studies in rabbits and rats using C-14-labelled TA and DMT showed: (1) rapid absorption and excretion of DA and DMT without evidence of tissue accumulation on single or repeated oral and intratracheal administration; (2) no skin irritation after single or repeated dermal application, and no significant skin absorption of TA; (3) recovery of 11-13% of the (single or repeated) cutaneous doses from urine and faeces within 10 days; (4) no significant absorption of TA after ocular instillation; (5) 33% excretion of a single ocular dose of DMT, with no evidence of tissue accumulation or eye damage. TA and DMT thus appeared to be rapidly absorbed and excreted without significant accumulation in the tissues. |
| Descriptors (primary) |
metabolic process; toxicology; dimethyl terephthalate; terephthalic acid |
| Descriptors (secondary) |
detection by radioactivity; routes of entry; body retention; animal experiments; excretion |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Phthalates
Esters and salts
|
