| Document ID (ISN) | 23857 |
| CIS number |
75-1669 |
| ISSN - Serial title |
0041-008X - Toxicology and Applied Pharmacology |
| Year |
1975 |
| Convention or series no. |
|
| Author(s) |
Feetam C.L., Leach R.H., Meynell M.J. |
| Title |
Lack of a clinically important interaction between warfarin and ascorbic acid. |
| Bibliographic information |
Mar. 1975, Vol.31, No.3, p.544-547. 8 ref. |
| Abstract |
The effect of high doses of ascorbic acid on anticoagulant control with warfarin sodium was investigated in 19 patient volunteers (11 men, 8 women, aged 40-82 years, average 61 years). Total plasma warfarin concentrations and prothrombin times were measured before, during, and after 7-day periods, when doses of 3, 5, and 10g ascorbic acid were taken daily with warfarin sodium. No clinically significant antagonism of the hypoprothrombinaemic action of warfarin occurs even when the doses of ascorbic acid taken concurrently are very high, although a fall in total plasma warfarin (2-40%, mean 17.5%) was observed. |
| Descriptors (primary) |
vitamin C; blood coagulation disorders; warfarin; drugs |
| Descriptors (secondary) |
determination in blood; human experiments |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Blood diseases
Heterocyclic compounds
|
