| Document ID (ISN) | 23748 |
| CIS number |
75-1560 |
| ISSN - Serial title |
Pathologia et Microbiologia |
| Year |
1975 |
| Convention or series no. |
|
| Author(s) |
Wirth T. |
| Title |
The effect of asbestos cement, UICC asbestos samples and quartz on the peritoneum of the mouse |
| Original title |
Die Wirkung von Asbestzement, UICC-Asbestproben und Quarz im Peritoneum der Maus [in German] |
| Bibliographic information |
1975, Vol.42, No.1, p.15-28. Illus. 48 ref. |
| Abstract |
This MD thesis reports on studies in which 7 types of dust (some UICC-standardised) were injected into the peritoneal cavity of mice. Aqueous suspensions of asbestos cement powder, chrysotile asbestos and chrysotile-asbestos-containing soil samples had a fibrogenic effect, the nodules resembling silicosis granulomas morphologically. In addition, asbestos cement had a strong cytotoxic effect during the first 2 weeks. It is suggested that this is due to the chrysotile asbestos and/or the calcite component of the powder. Amosite and crocidolite induced diffuse peritoneal fibrosis with the appearance of numerous foreign-body giant cells and asbestos bodies. Dust particles were frequently found in the regional lymph nodes of animals treated with quartz, asbestos cement and asbestos-containing soil samples. Spindle-cell-type sarcoma developed in the visceral peritoneum of animals injected with crocidolite or asbestos cement. Dusts containing chrysotile asbestos further induced considerable amyloidosis of the liver and spleen. |
| Descriptors (primary) |
carcinogens; peritoneum; asbestos cement; fibrosis; asbestos; dust; silica |
| Descriptors (secondary) |
Switzerland; amosite; chrysotile; crocidolite; sarcomas; histopathology; asbestos bodies; thesis; animal experiments; fibrogenic effects; cytotoxic effects; amyloidosis |
| Document type |
- |
| Subject(s) |
Dust, aerosols and related diseases
|
| Broad subject area(s) |
|
| Browse category(ies) |
Asbestos
Cement and concrete
|
