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Document ID (ISN)23654
CIS number 75-1693
ISSN - Serial title 0021-5082 - Japanese Journal of Hygiene - Nihon Eiseigaku Zasshi
Year 1974
Convention or series no.
Author(s) Fukushima M., Sakamoto M., Kobayashi E.
Title Urinary amino acid excretion in "Itai-itai" patients and inhabitants of cadmium polluted areas
Original title Kadomium osenti jumin no nyochyu-yuri-aminosan haisetsu ni tuite [in Japanese]
Bibliographic information Dec. 1974, Vol.29, No.5, p.498-504. Illus. 29 ref. (12 English).
Abstract Aminoaciduria was widespread among patients with Itai-itai disease (chronic cadmium poisoning) living in the Jinzu River Basin area polluted with cadmium and also in inhabitants with tubular proteinuria and glucosuria in the Ichi River Basin area, where cadmium pollution has also been observed. The amino acid patterns were similar in these cases and also resembled that reported in the Fanconi syndrome. The increase in amino acid excretion in these cases seems to be due to multiple disorders of the amino acid transport systems in the renal tubules, although increased hydroxyproline excretion is ascribed to a disturbance of amino acid metabolism.
Descriptors (primary) aminoaciduria; cadmium; urine monitoring; atmospheric pollution
Descriptors (secondary) Japan; amino acids; survey; metabolic disturbances; urinary excretion
Document type -
Subject(s) Occupational pathology
Broad subject area(s)
Browse category(ies) Inorganic substances
Cadmium and compounds
Environmental pollution
Biological monitoring
Air pollution
Diseases of the kidney and the urinary system