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CISDOC database

Document ID (ISN)23625
CIS number 75-1713
ISSN - Serial title 0005-9498 - Berufs-Dermatosen
Year 1974
Convention or series no.
Author(s) Simon N., Siklˇsi C.
Title The influence of environmental factors on porphyrin metabolism
Original title Beeinflussung des Porphyrinstoffwechsels durch Umweltfaktoren [in German]
Bibliographic information Nov.-Dec. 1974, No.6, p.237-259. Illus. 19 ref.
Abstract The effect of several pesticide compounds on the porphyrin metabolism in rats is examined. Hexachlorocyclohexane (HCH), hexachlorobenzene (HCB) and polychlorinated biphenyls (PCB) were found to induce porphyrin disorders. Other organo-chlorine compounds such as 2,4-dichlorophenoxy acetic acid (2,4-D) and pentachlorophenol (PCP) cause temporary coproporphyria, but no porphyrinogenic influence could be demonstrated. It appears that apolar chlorinated hydrocarbons (HCB, HCH, PCB) destroy the phospholipid structure of the cell membrane. As a result permeability to water-soluble precursors increases, causing the characteristic symptoms of porphyria cutanea tarda. Water-soluble poisons (2,4-D and PCB), which can be attacked by protohaem-containing oxydase enzymes, exert their effect through induction of the latter. This hypothesis is indirectly supported by the results of investigations on combined HCB and 2,4-D poisoning. Supposed membrane-damaging effects of HCB have also been confirmed by liposomal membrane permeability tests.
Descriptors (primary) pesticides; toxicology; chlorinated hydrocarbons; porphyrin metabolism; porphyria
Descriptors (secondary) hexachlorobenzene; polychlorinated biphenyls; pentachlorophenol; animal experiments; hexachlorocyclohexane; fragility of blood cells; porphyria cutanea tarda; dichlorophenoxyacetic acid
Document type -
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Metabolic diseases
Blood diseases
Halogenated hydrocarbons