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CISDOC database

Document ID (ISN)23545
CIS number 75-1429
ISSN - Serial title Japanese Journal of Agricultural Medicine
Year 1975
Convention or series no.
Author(s) Takahashi M., Inokuchi K., Kasakawa H., Wakai S., Kimura M.
Title Experimental studies on the effects of zineb and captan sprayed on rabbits in PVC-covered greenhouses.
Bibliographic information Dec. 1974, Vol.23, No.4, p.522-528. Illus. 17 ref.
Abstract Animal experiments were conducted in rabbits to study the toxicity of the pesticides zineb (zinc ethylenebisdithiocarbamate) and captan ((N-trichloromethylthio)cyclohex-4-ene-1,2-dicarboxyimide) over a period of 3 months. 4 groups of 7 rabbits were kept in PVC-covered greenhouses in which one of these compounds was sprayed for 30min once or twice a week. At the time of spraying, the zineb and captan concentrations in the greenhouse air were 0.35mg/m3 and 0.20mg/m3 respectively. Although no distinct abnormalities were found in the blood and urine of the animals exposed to captan, histopathological examinations showed significant infiltration of polymorphonuclear leucocytes and histiocytes in the lung interalveolar tissue, and eye and skin inflammation also occurred. No such abnormalities were seen in the group exposed to zineb.
Descriptors (primary) captan; zineb; horticulture; toxicology; pesticides
Descriptors (secondary) lung tissue reaction; histopathology; animal experiments; toxicity evaluation
Document type -
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Amides
Agriculture