| Document ID (ISN) | 23478 |
| CIS number |
75-1383 |
| ISSN - Serial title |
1775-8785 - Archives des maladies professionnelles |
| Year |
1974 |
| Convention or series no. |
|
| Author(s) |
Gabor S., Anca Z., Papilian V.V., Grecu F. |
| Title |
Morphological and functional modifications of the adrenal glands of rats due to the effect of cadmium and cadmium-zinc ions |
| Original title |
Modifications morphofonctionnelles des glandes surrénales chez le rat sous l'action des ions de cadmium et de cadmium-zinc. [in French] |
| Bibliographic information |
June 1974, Vol.35, No.6, p.641-646. 9 ref. |
| Abstract |
A study was carried out in rats exposed to 4 weekly doses (10mg/kg). The morphological and functional changes in the adrenal glands were determined by histological examinations, biochemical monitoring and functional tests. The histological examination revealed hypertrophy of the glands due to the effect of cadmium ions, affecting exclusively the fasciculated layer of the adrenal cortex. There was a reduction in ascorbic acid and lipids, which suggests impaired adrenal function. Thorn test results were negative; hypoglycaemia and reduced hepatic glycogen revealed impairment of the function of the glycocorticoid hormones. On the other hand, the combined action of Cd/Zn ions shows that zinc exerts a protective action. |
| Descriptors (primary) |
zinc; toxicology; adrenal function; cadmium; synergism |
| Descriptors (secondary) |
animal experiments; biochemical tests; histopathology |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Cadmium and compounds
Inorganic substances
|
