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CISDOC database

Document ID (ISN)23435
CIS number 75-1368
ISSN - Serial title 0009-9309 - Clinical Toxicology
Year 1974
Convention or series no.
Author(s) Wills J.H., Coulston F., Harris E.S., McChesney E.W., Russell J.C., Serrone D.M.
Title Inhalation of aerosolized ethylene glycol by man.
Bibliographic information Oct. 1974, Vol.7, No.5, p.463-476. Illus. 27 ref.
Abstract After a brief review of the literature and a description of the signs and symptoms observed after experimental ethylene glycol ingestion, the authors present their own experiments in humans, in which 19 male volunteers were exposed to aerosolized ethylene glycol in mean daily concentrations of 3-67mg/m3 almost continually for 4 weeks. Blood and urine examinations gave no evidence of the absorption of important quantities of ethylene glycol. There were no serious signs of toxicity but some complaints of irritation of the upper respiratory tract. Irritation became common with an ethylene glycol concentration of 140mg/m3, and more than 200mg/m3 was intolerable. It was concluded that an individual with normal sensory apparatus could not absorb a harmful quantity of ethylene glycol through the respiratory tract. Detailed results of laboratory and psychometric tests are given in tables.
Descriptors (primary) ethylene glycol; inhalation toxicity; toxicology
Descriptors (secondary) irritation; human experiments; aerosols
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Glycols
Alcohols