| Document ID (ISN) | 23308 |
| CIS number |
75-1330 |
| ISSN - Serial title |
Trudove na Instituta po higiena, ohrana na truda i profesionalni zaboljavanija |
| Year |
1974 |
| Convention or series no. |
|
| Author(s) |
Antov G., Zlateva M. |
| Title |
Changes in the levels of sulfhydryl groups and soluble proteins in certain internal organs of white rats under the combined effect of lead and arsenic |
| Original title |
Promeni v količestvoto na sulfhidrilnite grupi i raztvorimite beltăci v njakoi vătrešni organi na beli plăhove pri kombinirano dejstvie na olovo i arsen [in Bulgarian] |
| Bibliographic information |
1974, Vol.22, No.1, p.155-165. Illus. 22 ref. |
| Abstract |
Study of changes in the -SH and -S-S- groups and soluble proteins in liver, kidney, brain and small intestine homogenates of white rats exposed to arsenic trioxide in doses of 1/10 and 1/100 of the LD50 and to lead acetate (1/100 of the LD50), fed both separately and together, under conditions of subacute and chronic exposure. The combined action produced a fall in the levels of -SH groups and soluble proteins and an increase in -S-S- groups in the organs examined. These changes were proportional to the doses ingested and the duration of action. In the subacute test, the combined effect produced a fall in -SH groups and soluble proteins, closer to the effect of lead acetate, while in the chronic test synergism was marked. The changes observed are evidence of a disturbance of protein metabolism and redox processes. |
| Descriptors (primary) |
arsenic and compounds; lead and compounds; synergism; metabolic disturbances; toxicology |
| Descriptors (secondary) |
proteins; liver; arsenic; lead; kidney; animal experiments; in vitro experiments; brain; arsenic trioxide; lead acetate |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Inorganic substances
Endocrine diseases
Lead and compounds
Arsenic and compounds
|
