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CISDOC database

Document ID (ISN)23220
CIS number 75-1069
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1975
Convention or series no.
Author(s) Beatty P.W., Lembach K.J., Holscher M.A., Neal R.A.
Title Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on mammalian cells in tissue cultures.
Bibliographic information Feb.1975, Vol.131, No.2, p.309-312. 4 ref.
Abstract A study was made of this substance, a contaminant of the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5 T), to ascertain whether its toxic effect in mammals is due to inhibition of mitosis. In contrast with the results using plant endosperm cells, statistical analysis of growth rates and morphological studies using electron microscopy revealed no significant difference in growth patterns and no ultrastructural changes in the control or TCDD-treated cell lines studied.
Descriptors (primary) herbicides; cytotoxic effects; toxicology; tetrachlorodibenzodioxin
Descriptors (secondary) trichlorophenoxyacetic acid; electron microscopy; cell culture; in vitro experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Heterocyclic compounds
Agricultural chemicals