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Document ID (ISN)22722
CIS number 75-801
ISSN - Serial title 0430-8611 - Folia Facultatis Medicae Universitatis Comenianae Bratislaviensis
Year 1974
Convention or series no.
Author(s) Vargová M., Kovalčík V., Rosíval L., Kapeller K.
Title Concerning the toxicological evaluation of chlorinated insecticides
Original title K otázke toxikologického hodnotenia chlórovaných insekticídov [in Slovak]
Bibliographic information 1974, Vol.12, No.1, p.5-53. Illus. 101 ref.
Abstract Using heptachlor as an example, the authors studied the problem of the quantitative evaluation of the toxicity of chlorinated insecticides. They established that LT50, defined as the time required for the dose administered to cause the death of 50% of the experimental animals, can be used as a criterion for determining the toxicity of substances administered in repeated doses. Log LT50 is a linear function of the dose in accordance with the relation log LT50 = log C-n log D (where D is the repeated dose, C and n being constants). The value of n is particularly important for assessing safe limits, because it depends not only on the nature of the substance, but also on the frequency and mode of administration, and the variety, species and sex of the animal. Part of the article is devoted to the influence of prior administration of heptachlor on the efficacy and toxicity of analgesics and barbiturates.
Descriptors (primary) insecticides; toxicity evaluation; chlorinated hydrocarbons; toxicology
Descriptors (secondary) lethal time 50; heptachlor; synergism; barbiturates; animal experiments; analgesics
Document type -
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s)
Browse category(ies) Halogenated hydrocarbons
Agricultural chemicals