| Document ID (ISN) | 22589 |
| CIS number |
75-454 |
| ISSN - Serial title |
0041-008X - Toxicology and Applied Pharmacology |
| Year |
1974 |
| Convention or series no. |
|
| Author(s) |
Kociba R.J., McCollister S.B., Park C., Torkelson T.R.
Gehring P.J. |
| Title |
1,4-Dioxane - I. Results of a 2-year ingestion study in rats. |
| Bibliographic information |
Nov. 1974, Vol.30, No.2, p.275-286. Illus. 10 ref. |
| Abstract |
Rats have been maintained on drinking water containing 0.00 (controls), 0.01, 0.1 or 1.0% 1,4-dioxane for 2 years in order to characterise the indices to toxicity. Rats receiving 1% dioxane showed pronounced toxic effects including the occurrence of hepatic and nasal tumours. There was an induction of liver and kidney damage, but no tumour formation in rats receiving 0.1% dioxane. No evidence of untoward toxic effects was observed in rats receiving 0.01% dioxane. These data indicate a clearcut dose-response relationship for the toxicity of dioxane. |
| Descriptors (primary) |
carcinogens; ingestion; toxicology; dioxane |
| Descriptors (secondary) |
hepatotoxic effects; nasal cancer; liver cancer; nephrotoxic effects; long-term study; dose-response relationship; animal experiments |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Ethers
|
