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CISDOC database

Document ID (ISN)22587
CIS number 75-452
ISSN - Serial title 0041-008X - Toxicology and Applied Pharmacology
Year 1974
Convention or series no.
Author(s) Lindquist N.G.
Title An autoradiographic study on the distribution of the herbicide 4-chloro-2-methylphenoxyacetic acid in pregnant mice.
Bibliographic information Nov. 1974, Vol.30, No.2, p.227-236. Illus. 20 ref.
Abstract The toxicity of the phenoxy herbicides has been reported to be moderate but teratogenic effects have been produced in rodents by 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), 2,4-dichlorophenoxyacetic acid (2,4-D) derivatives and 4-chloro-2-methylphenoxyacetic acid ethyl ester (MCPA). The distribution of 2,4,5-T and 2,4-D in experimental animals has already been investigated. In this study whole-body autoradiography was used to ascertain the distribution of radioactivity after injection of MCPA in pregnant mice. The distribution of MCPA was found to be very similar to that observed for 2,4,5-T and 2,4-D. The results indicate a teratogenic mode of action for MCPA similar to that postulated for 2,4,5-T, i.e. inhibition of the embryotrophic nutrition.
Descriptors (primary) herbicides; chloromethylphenoxyacetic acid; radioautography; toxicology; genetic effects; metabolic process
Descriptors (secondary) ethyl 4-chloro-2-methylphenoxyacetate; dichlorophenoxyacetic acid; teratogenic effects; animal experiments; trichlorophenoxyacetic acid
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects