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Document ID (ISN)22572
CIS number 75-507
ISSN - Serial title 0040-6376 - Thorax
Year 1974
Convention or series no.
Author(s) Smith P., Heath D.
Title Paraquat lung: a reappraisal.
Bibliographic information Nov. 1974, Vol.29, No.6, p.643-653. Illus. 20 ref.
Abstract Poisoning by paraquat commonly leads to the development of pulmonary fibrosis often described as being interstitial in nature and regarded by many as an example of fibrosing alveolitis. However, the experimental evidence from rats, together with observations on 4 human cases presented here, suggest that the basic pathological change in the human lung due to paraquat poisoning is a diffuse, cellular intra-alveolar fibrosis and not fibrosing alveolitis. It is shown to be associated with pulmonary vascular pathology. In assessing the histopathology of the lung in paraquat poisoning, a history of oxygen therapy must be taken into account as prolonged exposure to this gas may in itself induce pulmonary fibrosis.
Descriptors (primary) herbicides; histopathology; pulmonary fibrosis; paraquat
Descriptors (secondary) case study; oxygen; animal experiments; paraquat chloride
Document type -
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Diseases of the respiratory system (except for pneumoconiosis & similar)
Heterocyclic compounds