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Document ID (ISN)22354
CIS number 75-173
Year 1974
Convention or series no.
Author(s) Kolmodin-Hedman B.
Title Exposure to lindane and DDT and its effects on drug metabolism and serum lipoproteins.
Bibliographic information Kungliga Arbetarskyddsstyrelsen, Fack, 100 26 Stockholm 34, Sweden, 1974. 48p. Illus. 125 ref.
Abstract Thesis reporting the results of investigations into the occupational exposure of various groups of Swedish workers to lindane and DDT. The author devised a gas-liquid chromatographic method for estimating values as low as 0.3ng/ml of lindane and 3ng/ml of DDT in human plasma. DDT levels in samples taken 8 months after exposure did not differ from those in samples taken during exposure. To elucidate the effect of lindane and DDT exposure on drug metabolism, plasma half-lives were determined for antipyrine, phenylbutazone and oxazepam. The plasma half-life of antipyrine was significantly reduced by lindane exposure. It is thought that lindane induces drug oxidation in man. An unusual change of the serum lipoprotein pattern was found in 12 of 34 insecticide-exposed men: hyper-alpha-lipoproteinaemia, which was confirmed by animal experiments.
Descriptors (primary) metabolic process; DDT; exposure evaluation; drugs; insecticides; lindane
Descriptors (secondary) literature survey; Sweden; gas-liquid chromatography; thesis; determination in blood; lipoproteins
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Exposure evaluation
Halogenated hydrocarbons