| Document ID (ISN) | 22308 |
| CIS number |
75-155 |
| ISSN - Serial title |
Gigiena truda i professional'nye zabolevanija |
| Year |
1974 |
| Convention or series no. |
|
| Author(s) |
Pavlenko G.I., Osina S.A., Voroncov R.S. |
| Title |
Respiratory toxicity of triphthazine in animal experiments |
| Original title |
Ingalacionnoe vozdejstvie triftazina v uslovijah ėksperimenta na životnyh [in Russian] |
| Bibliographic information |
Apr. 1974, No.4, p.27-30. 5 ref. |
| Abstract |
The drug triphthazine is a piperazine derivative of phenothiazine. Studies in albino rats have shown that inhalation of 1.5mg/m3 of triphthazine has an effect on the central nervous system. Chronic exposure of the animals to 0.06mg/m3 produces loss of bodyweight, elevated rectal temperature, a fall in leucocyte and erythrocyte levels, slowing of the respiratory rate and a considerable increase in diuresis. On the basis of the results obtained, the authors recommend the adoption of a threshold limit value of 0.01mg/m3. |
| Descriptors (primary) |
neurotoxic effects; toxicology; triphthazine; drugs |
| Descriptors (secondary) |
threshold limit values; long-term exposure; animal experiments; pollakiuria |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Diseases of the nervous system
Heterocyclic compounds
|
