| Document ID (ISN) | 22205 |
| CIS number |
75-126 |
| ISSN - Serial title |
Works of the United Research Institute of Hygiene and Industrial Safety |
| Year |
1972 |
| Convention or series no. |
|
| Author(s) |
Petrova-Vergieva T., Ivanova-Chemishanska L. |
| Title |
The effect of maneb on intrauterine development of rats. |
| Bibliographic information |
1972, Vol.23, p.65-70. 5 ref. |
| Abstract |
A single dose of the fungicide maneb (manganese diethyldithiocarbamate) administered to pregnant female rats during the phase of organogenesis induces nervous-system and skeleton malformations in the foetus (exencephalia, encephalocele, cheilognathopalatoschisis, phocomelia, amelia, ectrodactylism, microcaudia, acaudia, etc.). Doses corresponding to 2/3, 1/3 and 1/6 of the lethal dose 50 (6g/kg for adult rats) proved to be teratogenic. A dose corresponding to 1/12 LD50, both single and repeated, did not affect gestation. |
| Descriptors (primary) |
maneb; teratogenic effects; fungicides; toxicology |
| Descriptors (secondary) |
animal experiments |
| Document type |
- |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
|
| Browse category(ies) |
Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Amides
|
