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CISDOC database

Document ID (ISN)22205
CIS number 75-126
ISSN - Serial title Works of the United Research Institute of Hygiene and Industrial Safety
Year 1972
Convention or series no.
Author(s) Petrova-Vergieva T., Ivanova-Chemishanska L.
Title The effect of maneb on intrauterine development of rats.
Bibliographic information 1972, Vol.23, p.65-70. 5 ref.
Abstract A single dose of the fungicide maneb (manganese diethyldithiocarbamate) administered to pregnant female rats during the phase of organogenesis induces nervous-system and skeleton malformations in the foetus (exencephalia, encephalocele, cheilognathopalatoschisis, phocomelia, amelia, ectrodactylism, microcaudia, acaudia, etc.). Doses corresponding to 2/3, 1/3 and 1/6 of the lethal dose 50 (6g/kg for adult rats) proved to be teratogenic. A dose corresponding to 1/12 LD50, both single and repeated, did not affect gestation.
Descriptors (primary) maneb; teratogenic effects; fungicides; toxicology
Descriptors (secondary) animal experiments
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Amides