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CISDOC database

Document ID (ISN)22204
CIS number 75-125
ISSN - Serial title Works of the United Research Institute of Hygiene and Industrial Safety
Year 1972
Convention or series no.
Author(s) Ivanova-Chemishanska L., Kaloyanova F., Izmirova N., Zlateva M., Valcheva V.
Title Experimental inhalatory toxicity and substantiation of the maximum allowable concentration for some dithiocarbamates in the air of the working area.
Bibliographic information 1972, Vol.23, p.55-64. Illus. 14 ref.
Abstract Results of animal experiments carried out with a view to assessing the inhalation toxicity of zineb, maneb and mancozeb, and to establishing threshold limit values for long-term exposure. Toxic effects consisted of inflammatory, and sometimes ulcerative, changes in the trachea, inflammatory vascular damage to the lung which sometimes degenerated into emphysematous and atelectatic changes, hepatotoxic and nephrotoxic changes (severity according to concentration). Maneb and mancozeb, which contain manganese, have a more severe toxic action on the respiratory tract and other parenchymatous organs than zineb. The following threshold limit values are recommended: 1mg/m3 for zineb; 0.4mg/m3 for maneb; 0.5mg/m3 for mancozeb.
Descriptors (primary) threshold limit values; fungicides; toxicology; dithiocarbamates
Descriptors (secondary) maneb; mancozeb; determination of exposure limits; animal experiments; zineb
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Occupational exposure limits