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Document ID (ISN)22111
CIS number 75-106
ISSN - Serial title 0009-0514 - Československá dermatologie
Year 1973
Convention or series no.
Author(s) Jirásek L., Kalenský J., Kubec K.
Title Chloracne and porphyria cutanea tarda in herbicide production
Original title Acne chlorina a porphyria cutanea tarda při výrobě herbicid [in Czech]
Bibliographic information Oct. 1973, Vol.48, No.5, p.306-317. 49 ref.
Abstract Detailed description of 78 cases (2 of which were fatal) of chloracne involving in some cases liver damage, impairment of the metabolism of porphyrins, lipids and proteins, and nervous and psychic complications, observed between 1965 and 1968 among workers of various ages employed in a plant where chlorinated organic substances (pentachlorophenol and 2,4,5-trichlorophenoxyacetic acid) were used in the manufacture of herbicides. It was found that these disturbances were due to the action of the 2,3,6,7-tetrachlorodibenzodioxin which is formed on alkaline hydrolysis of tetrachlorobenzene to produce sodium trichlorophenolate. To prevent the formation of this compound, hydrolysis should be carried out at 153°C (instead of 190°C). The paper includes a wide literature survey on the effects of poisoning by chlorinated organic compounds, especially dermatitis.
Descriptors (primary) herbicides; porphyria cutanea tarda; pesticide production; chlorinated hydrocarbons; chloracne
Descriptors (secondary) literature survey; case study; hepatic damage; pentachlorophenol; fatalities; tetrachlorodibenzodioxin; metabolic disturbances; dermatitis; neuropsychic effects; trichlorophenoxyacetic acid
Document type -
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Agricultural chemicals
Chemical industry
Skin diseases
Metabolic diseases
Halogenated hydrocarbons